The Binding Of Isaac: Repentance is the third and final expansion for the Binding of Isaac series. It wraps up the story and adds hundreds of new items, trinkets, two new characters, and new paths for the player to take – there is a lot of new content in Repentance.
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While some fans claim the new expansion is much more difficult than Afterbirth or Afterbirth+, there are many new items that either flat out break the game or combine well with just about anything. Edmund McMillen, the creator of the game, even said that the new meta's difficulty is meant to force fans to try new methods of completing runs.
10 Eye of the Occult
The Eye of the Occult item is very similar to the Ludovico Technique except that Isaac can fire more than one tear to control. Additionally, the Eye of the Occult increases Isaac's damage by 1 and his range by 7.5, but it reduces his shot speed slightly.
The tears are controllable while in flight, which are otherwise like normal tears and are affected by Isaac's range – but the item does have special interactions with other items like Brimstone. It's found only in the Devil Room, or with items that spawn Devil Room chests.
9 Rock Bottom
Rock Bottom is a passive item that simply prevents the player's stats from being reduced by anything for the rest of the run. It pairs extremely well with Experimental Treatment by removing all downsides, as the item randomly increases and decreases stats.
However, while the item prevents outright stat reductions (e.g. from pills) it won't stop multipliers from lowering the player's damage. If an item multiplies the player's damage by a percentage below 1, Rock Bottom doesn't keep the original number. It can only be found in the Secret Room.
8 Immaculate Heart
The Immaculate Heart gives Isaac a chance to shoot additional tears that orbit around him, defending him from close-by enemies. It also gives Isaac an extra red heart and adds an extra 20 percent damage to his shots.
The Immaculate Heart would be a bit forgettable if not for the damage boost and extra health, and its extra ability to give Isaac orbiting tears bumps it above others significantly. The item is only found in Angel Rooms.
7 Member Card
The Member Card is an item that opens a special shop underneath the regular shop on each level. The item causes a trapdoor to spawn, which reveals the additional shop. It can contain up to 5 items, including trinkets, items, cards, runes, and various types of hearts.
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Each pedestal item in the room costs more than usual, anywhere from 15 to 30 cents for normal items and up to 99 cents for Secret Room items. The Member Card is unlocked by spending 40 coins in a single shop.
6 Genesis
Genesis is functionally a way to reset a run in the middle of the run. It teleports Isaac to a bedroom with two chests, two sacks, a trinket and a trap door that takes him to the next layer down (without having to clear the floor Isaac teleported from).
The item takes away every single item Isaac picked up in the run and offers a choice of three items for each one taken away. At its worst, it's an item that will change how you play the rest of the run. At it's best, it flat-out breaks the game with the huge array of synergies presented.
5 Mega Mush
The Mega Mush is a new mushroom-type item in The Binding Of Isaac: Repentance and, like the other mushrooms, significantly affects the player's stats. When this active item is used, it makes Isaac turn gigantic for half a minute and increases his damage fourfold.
However, while the player is far more powerful and has a much longer range, the tear delay stat is also multiplied by 2.5 times. The slow shoot speed is balanced by the fact that Isaac turns invincible, deals contact damage, and can destroy just about anything in his path. To unlock this, the player must complete hard mode with all characters.
4 4.5 Volt
The 4.5 Volt is a passive item that changes the way the charge on active items works. Instead of gaining charge when completing rooms or picking up batteries, Isaac's active item charges when he deals damage to enemies.
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His item will charge one bar's worth for every 60 damage that Isaac deals to enemies. It should be unlocked from the get-go upon downloading Repentance.
3 False PHD
The False PHD is very similar to the PHD item, but with a twist. They both identify pills before they are picked up, but whereas the PHD item gets rid of all negative pills in the game, the False PHD gets rid of every positive pill.
Each pill that would normally cause a stat down also gives Isaac a small permanent damage boost. It gives one black pill when picked up, and can only be found in the Curse Room, the Devil Room, or in red chests.
2 Soul Locket
The Soul Locket is a slow-burning item, but one that becomes more powerful the earlier in the run it is acquired. This item gives Isaac a small increase to a random stat (except health and shot height) whenever a Soul Heart is picked up.
It doesn't apply to alternative hearts like Black Hearts or Bone Hearts, and it doesn't work with items that give Isaac Soul Hearts directly. To unlock the Soul Locket, beat Ultra Greed while playing as Bethany.
1 Sacred Orb
The Sacred Orb is a very simple but very, very powerful item. When picked up, for the rest of the run every item Isaac finds will be of a higher quality than normal. In the game's code, every item is assigned a ranking from zero to four, zero being awful items and four being overpowered items.
The Sacred Orb will automatically re-roll items with a quality score of zero or one, and has a one-third chance to re-roll items with a quality score of two. It's not a guaranteed victory, but it's incredibly useful to just cut out a huge number of useless or situational items.
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