The Reverend Mother Gaius Helen Mohiam had no sooner arrived at Castle Caladan than she brought up the Orange Catholic Bible's commandment against thinking machines. A Reverend Mother of the Bene Gesserit — a powerful secretive all-female order — she is committed to, among other things, training and honing human talents, sifting humans from people by testing for them, and therefore preventing the enslavement of "men" by thinking machines.