It's no secret that Spider-Man has one of the best rogue's galleries in all of comic book history, with a slew of household names like Green Goblin, Venom, and Doc Ock. It's a given, then, that in a Spider-Man game fans will get to face off against at least a handful of iconic Spidey foes. In the vast majority of past Spider-Man games, this almost always results in players going up against some variation of the Sinister Six, whether they've officially become a team or not. The old 2004 Spider-Man 2 game had Rhino, Doc Ock, Mysterio, and Shocker, while Ultimate Spider-Man had the Ultimate version of the Six, and even Insomniac set players against its own version of the villain team. But Marvel's Spider-Man 2 switches things up a little.