Marvel's Spider-Man 2 does a great job of paying homage to many classic characters throughout the Marvel franchise, and Spider-Man is particularly notable for having a massive cast of characters spread out across near-infinite universes via the Spider-Verse. While Marvel's Spider-Man 2 does feature some iconic characters like Harry Osborn, Dr. Curt Connors, and even a teaser for Cindy Moon, other characters are absent or only referenced via Easter eggs. The fan-favorite Gwen Stacy is one of these characters, but she is referenced in a small way that Spider-Man 2 players can uncover by following one side quest.