Cartoon Network’s beloved animated series The Powerpuff Girls was slated to be produced as a live-action series for CW, but development ended after a few setbacks. Created by animator Craig McCracken, The Powerpuff Girls is an animated series that follows the heroics of three lab-created little girls with superpowers. It’s a show that was born for animation. Trying to adapt it for live-action may have been the filmmakers' first misstep.