Debuting back in 2008 with the first Dead Space, Isaac Clarke quickly became one of the most iconic horror gaming characters of all time, and he didn't even speak a word. Thanks largely in part to the character's unique exoskeleton design, along with realistic character animations, Isaac Clarke became the new standard for modern horror gaming protagonists, being both iconic and grounded in equal measure. Though Isaac Clarke's prominence in the gaming space faltered a little in the last decade or so, last year's Dead Space remake has brought him back into the spotlight.