Mass Effect 4 is well on its way, and while it's not entirely clear what the game is going to look like, fans can be fairly certain that it will take place in the Milky Way and will likely serve as a direct sequel to Mass Effect 3. It remains to be seen just how closely Mass Effect 4 will be linked to the other games in terms of narrative, but its setting and ostensible premise mean that it will have to contend with a few lore hurdles while introducing new storytelling elements.