The trailer for State of Decay 3 offered a few hints that the plague may have developed some new effects between games. The Plague Hearts and the rot that they spread was one of the overarching threats in State of Decay 2, so the plague's return in its sequel would be unsurprising. However, State of Decay 3 may see players dealing with a new kind of plague. The effects could range from a few cosmetic changes to some serious new dangers. State of Decay 3's plague could end up giving players their greatest obstacle in the series' history.