With over 100 Challenges in the Resident Evil 4 remake, players can easily become overwhelmed when planning their playthroughs and focusing on the most essential or rewarding aspects. Naturally, they want to know which Challenges are worth the grind and effort. To address this, the following list ranks the best Challenges in the RE4 remake based on the rewards they offer. By prioritizing these objectives, beginners can unlock the most notable items early on and enhance their enjoyment in New Game Plus playthroughs.