Following on from its September release, The Substance became one of 2024's highest-earning movies at the box office, accumulating more than $34 million worldwide. Not only was it provocative, bloody, and disgusting, but horror fans and critics alike sang its praises due to how smart and insightful it was, highlighting many issues facing society, especially for women. Among its well-deserved glory, will The Substance get a part two? Thankfully, its director has spoken up about a possible sequel.