At the end of Cyberpunk 2077's prologue, V will have to make a difficult decision regarding Jackie. After a sudden and sad sequence of events, V must decide where to send him, and the two options lead to different outcomes further down the line. This article contains spoilers for Cyberpunk 2077.
During the heist that V and Jackie have been assigned to by notable fixer Dexter DeShawn, the unthinkable happens when Jackie and V finally get inside Yorinobu Arasaka's apartment and it sends the entire building into lockdown mode. In what was supposed to be a simple stealth pickup turned into the duo having to shoot their way out of Arasaka Tower, and Jackie is fatally shot. This probably isn't surprising to many players; there were death flags flying everywhere during the drive up, such as with the Delamain vehicle explaining that a dead body can be transported to any chosen location. As the foreshadowing may have suggested, this is what V needs to decide after the heist.
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Thanks to Delamain's Excelsior package provided by Dex, V has two places they can send Jackie's body after he passes: either to his family's or Vik's. While there is one clear-cut option that is better than the other, it's worth noting off the bat that, either way, Mama Welles will still offer V Jackie's bike after the ceremony.
In general, the more respectable option is sending Jackie to his mom after he passes, but this will also unlock a side quest in Cyberpunk 2077 that cannot be unlocked otherwise. Sending Jackie's remains to his family will result in Mama Welles inviting V over for a ceremony in a quest called Heroes. V will meet Mama Welles prior to the ceremony, and she'll ask V to find something of Jackie's to bring to the ofrenda.
V will also meet with Misty again, who will be waiting outside Jackie's garage and will offer some insights to his belongings. V and Misty have some heartfelt conversations, during which V can try to smooth over Misty's relationship with Jackie's mother. After picking an item for the ofrenda, V can say a few words for Jackie at the ceremony and talk with some others who were close with him.
If V chooses to send Jackie's body to Vik's, their ripperdoc, V will be locked out of the bulk of the Heroes side quest. Instead, Mama Welles will leave a box outside of V's that contains the key to Jackie's bike. V can call Mama Welles, who won't be upset with the decision and will still wish V the best.
Cyberpunk 2077 is available now for PC, PS4, Stadia, and Xbox One, with PS5 and Xbox Series X versions in development.