When the first official trailer for Thymesia came out in March 2021, many were head-over-heels about a new Souls-like featuring a plague doctor protagonist. The history surrounding plague doctors is often explored in video games, and Thymesia does this in an interesting way, applying the concept of bloodletting to how players can regain their resources. Another interesting aspect is how players can change their playstyle by manifesting plague weapons, including a huge scythe, claws, and more.