Marvel's Guardians of the Galaxy came out of nowhere last year, surprise revealed at E3 2021 and then launched a few months later to strong reviews. Guardians of the Galaxy even took home the Game Award for Best Narrative, with many fans interested to see what this version of Marvel's cosmic crew would get up to in a sequel. No Guardians of the Galaxy sequel plans have been made public, but if one ever materializes, it has an obvious choice for its villain. SPOILERS for the Guardians of the Galaxy game follow.